Prolongation of Hippocampal Miniature Inhibitory Postsynaptic Currents in Mice Lacking the GABAA Receptor 1 Subunit
نویسندگان
چکیده
PETER A. GOLDSTEIN, FRANK P. ELSEN, SHUI-WANG YING, CAROLYN FERGUSON, GREGG E. HOMANICS, AND NEIL L. HARRISON C. V. Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, New York 10021; and Department of Anesthesiology and Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261
منابع مشابه
Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit.
GABA(A) receptors (GABA(A)-Rs) are pentameric structures consisting of two alpha, two beta, and one gamma subunit. The alpha subunit influences agonist efficacy, benzodiazepine pharmacology, and kinetics of activation/deactivation. To investigate the contribution of the alpha1 subunit to native GABA(A)-Rs, we analyzed miniature inhibitory postsynaptic currents (mIPSCs) in CA1 hippocampal pyrami...
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Ramadan, Epolia, Zhanyan Fu, Gabriele Losi, Gregg E. Homanics, Joseph H. Neale, and Stefano Vicini. GABAA receptor 3 subunit deletion decreases 2/3 subunits and IPSC duration. J Neurophysiol 89: 128–134, 2003. 10.1152/jn.00700.2002. Deletion of the 3 subunit of the GABAA receptor produces severe behavioral deficits and epilepsy. GABAA receptor-mediated miniature inhibitory postsynaptic currents...
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